Article
Molecular imaging of active mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2011
Yeh Hsin Hsien, Ogawa Kazuma, Balatoni Julius, Mukhapadhyay Uday, Pal Asutosh, Gonzalez-Lepera Carlos, Shavrin Aleksandr, Soghomonyan Suren, Flores Leo, Young Daniel, Volgin Andrei Y, Najjar Amer M, Krasnykh Victor, Tong William, Alauddin Mian M, Gelovani Juri G
Abstract excerpt
The importance of the EGF receptor (EGFR) signaling pathway in the development and progression of nonsmall cell lung carcinomas (NSCLC) is widely recognized. Gene sequencing studies revealed that a majority of tumors responding to EGFR kinase inhibitors harbor activating mutations in the EGFR kinase domain. This underscores the need for novel biomarkers and diagnostic imaging approaches to identify patients who...
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