Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Image-Based Phenotypic Profiling Enables Rapid and Accurate Assessment of EGFR-Activating Mutations in Tissues from Lung Cancer Patients.

Journal of the American Chemical Society - 5 Feb 2025

Lei Qian, Zhou Xinglong, Li Ying, Zhao Shuang, Yang Na, Xiao Zhaolin, Song Chao, Yu Quanwei, Deng Hui

Abstract excerpt

Determining mutations in the kinase domain of the epidermal growth factor receptor (EGFR) is critical for the effectiveness of EGFR tyrosine kinase inhibitors (TKIs) in lung cancer. Yet, DNA-based sequencing analysis of tumor samples is time-consuming and only provides gene mutation information on EGFR, making it challenging to design effective EGFR-TKI therapeutic strategies. Here, we present a new image-based...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to EGFR gene

Share to Lung Neoplasms

Share to Mutation

Share to Phenotype

Share to Protein Kinase Inhibitors

Source

Identifiers

PMID: 39745025
DOI: 10.1021/jacs.4c16528

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Image-Based Phenotypic Profiling Enables Rapid and Accurate Assessment of EGFR-Activating Mutations in Tissues from Lung Cancer Patients.PMID 39745025Read ↗

Expanded Application of a Photoaffinity Probe to Study Epidermal Growth Factor Receptor Tyrosine Kinase with Functional Activity.Semantic proximity Read ↗

A fluorogenic probe for predicting treatment response in non-small cell lung cancer with EGFR-activating mutations.Semantic proximity Read ↗

Identification of Disease States and Response to Therapy in Humans by Utilizing the Biomarker EGFR for Targeted Molecular Imaging.Semantic proximity Read ↗

Potential applications of clickable probes in EGFR activity visualization and prediction of EGFR-TKI therapy response for NSCLC patients.Semantic proximity Read ↗

Quantum Cascade Laser-Based Infrared Imaging as a Label-Free and Automated Approach to Determine Mutations in Lung Adenocarcinoma.Semantic proximity Read ↗

A PET imaging approach for determining EGFR mutation status for improved lung cancer patient management.Semantic proximity Read ↗

Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies.Semantic proximity Read ↗

Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer.Semantic proximity Read ↗

Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometrySemantic proximity Read ↗

EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models.Semantic proximity Read ↗

Mutation and drug-specific intracellular accumulation of EGFR predict clinical responses to tyrosine kinase inhibitors.Semantic proximity Read ↗

Image-based phenotypic profiling of a chemogenomic screening library identifies novel druggable targets in the EGFR-pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.