Article
Molecular imaging of nonsmall cell lung carcinomas expressing active mutant EGFR kinase using PET with [(124)i]-morpholino-IPQA.
BioMed research international - 1 Jan 2013
Yeh Skye Hsin-Hsien, Lin Chien-Feng, Kong Fan-Lin, Wang Hsin-Ell, Hsieh Ya-Ju, Gelovani Juri G, Liu Ren-Shyan
Abstract excerpt
Mutations in the kinase domain of epidermal growth factor receptor (EGFR) have high levels of basal receptor phosphorylation and are associated with clinical responsiveness to Iressa in patients with nonsmall cell lung cancer (NSCLC). This study aimed to assess the feasibility of morpholino-[(124)I]IPQA derivative as an in vivo PET imaging tool for the expression of different EGFR mutants in NSCLC. In vitro...
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