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Article

First-in-Humans PET Imaging of KRASG12C Mutation Status in Non-Small Cell Lung and Colorectal Cancer Patients Using [18F]PFPMD.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Dec 2023

Li Xiang, Ye Jiajun, Wang Jingyi, Quan Zhiyong, Li Guiyu, Ma Wenhui, Zhang Mingru, Yang Weidong, Wang Junling, Ma Taoqi, Kang Fei, Wang Jing

Abstract excerpt

Kirsten rat sarcoma (KRAS) mutations are an important marker for tumor-targeted therapy. In this study, we sought to develop a KRASG12C oncoprotein-targeted PET tracer and to evaluate its translational potential for noninvasive imaging of the KRASG12C mutation in non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) patients. Methods: [18F]PFPMD was synthesized on the basis of AMG510 (sotorasib) by...

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PMID: 37827842
DOI: 10.2967/jnumed.123.265715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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