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Article

Potential applications of clickable probes in EGFR activity visualization and prediction of EGFR-TKI therapy response for NSCLC patients.

European journal of medicinal chemistry - 15 Feb 2022

Deng Hui, Lei Qian, Shang Weidong, Li Ying, Bi Liyun, Yang Na, Yu Zhiyi, Li Weimin

Abstract excerpt

The epithelial growth factor receptor (EGFR) is abnormally overexpressed on the cell surface of cancer cells and is strongly associated with cancer cell proliferation, migration, differentiation, apoptosis, and angiogenesis. Tools enabling the visualization of EGFR in a structure-function approach are highly desirable to predict EGFR mutations and guide EGFR tyrosine kinase inhibitor (TKI) treatment making. Here,...

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Source

Identifiers

PMID: 35007861
DOI: 10.1016/j.ejmech.2022.114100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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