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Article

Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.

Nature chemical biology - 1 Apr 2007

Blair Jimmy A, Rauh Daniel, Kung Charles, Yun Cai-Hong, Fan Qi-Wen, Rode Haridas, Zhang Chao, Eck Michael J, Weiss William A, Shokat Kevan M

Abstract excerpt

As key components in nearly every signal transduction pathway, protein kinases are attractive targets for the regulation of cellular signaling by small-molecule inhibitors. We report the structure-guided development of 6-acrylamido-4-anilinoquinazoline irreversible kinase inhibitors that potently and selectively target rationally designed kinases bearing two selectivity elements that are not found together in any...

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PMID: 17334377
DOI: 10.1038/nchembio866

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EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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