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Article

A PET imaging approach for determining EGFR mutation status for improved lung cancer patient management.

Science translational medicine - 7 Mar 2018

Sun Xilin, Xiao Zunyu, Chen Gongyan, Han Zhaoguo, Liu Yang, Zhang Chongqing, Sun Yingying, Song Yan, Wang Kai, Fang Fang, Wang Xiance, Lin Yanhong, Xu Lili, Shao Liming, Li Jin, Cheng Zhen, Gambhir Sanjiv Sam, Shen Baozhong

Abstract excerpt

Tumor heterogeneity and changes in epidermal growth factor receptor (EGFR) mutation status over time challenge the design of effective EGFR tyrosine kinase inhibitor (TKI) treatment strategies for non-small cell lung cancer (NSCLC). Therefore, there is an urgent need to develop techniques for comprehensive tumor EGFR profiling in real time, particularly in lung cancer precision medicine trials. We report a...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Positron Emission Tomography Computed Tomography

Source

Identifiers

PMID: 29515002
DOI: 10.1126/scitranslmed.aan8840

Genes

EGFR
MPG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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