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Article

Monitoring of gefitinib sensitivity with radioiodinated PHY based on EGFR expression.

Biological & pharmaceutical bulletin - 1 Jan 2014

Yoshimoto Mitsuyoshi, Hirata Masahiko, Kanai Yasukazu, Naka Sadahiro, Nishii Ryuichi, Kagawa Shinya, Kawai Keiichi, Ohmomo Yoshiro

Abstract excerpt

Epidermal growth factor receptor (EGFR) is attractive target for tumor diagnosis and therapy, as it is specifically and abundantly expressed in tumor cells. EGFR-tyrosine kinase (TK) inhibitors such as gefitinib and erlotinib are widely used in the treatment of non-small cell lung cancer (NSCLC). In this study, we investigated whether radioiodinated 4-(3-iodo-phenoxy)-6,7-diethoxy-quinazoline (PHY), which is a...

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Identifiers

PMID: 24583857
DOI: 10.1248/bpb.b13-00559

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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