Article
Both Schwann cell and axonal defects cause motor peripheral neuropathy in Ebf2-/- mice.
Neurobiology of disease - 1 Apr 2011
Giacomini Caterina, La Padula Veronica, Schenone Angelo, Leandri Massimo, Contestabile Andrea, Moruzzo Diego, Goutebroze Laurence, Consalez G Giacomo, Benfenati Fabio, Corradi Anna
Abstract excerpt
Charcot-Marie-Tooth neuropathies are frequent hereditary disorders of the nervous system and most cases remain without a molecular definition. Mutations in transcription factors have been previously associated to various types of this disease. Mice carrying a null mutation in Ebf2 transcription factor present peripheral nerve abnormalities. To get insight into Ebf2 function in peripheral nervous system, here we...
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