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Article

Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells.

Brain : a journal of neurology - 1 Dec 2012

Horn Michael, Baumann Reto, Pereira Jorge A, Sidiropoulos Páris N M, Somandin Christian, Welzl Hans, Stendel Claudia, Lühmann Tessa, Wessig Carsten, Toyka Klaus V, Relvas João B, Senderek Jan, Suter Ueli

Abstract excerpt

Studying the function and malfunction of genes and proteins associated with inherited forms of peripheral neuropathies has provided multiple clues to our understanding of myelinated nerves in health and disease. Here, we have generated a mouse model for the peripheral neuropathy Charcot-Marie-Tooth disease type 4H by constitutively disrupting the mouse orthologue of the suspected culprit gene FGD4 that encodes...

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Identifiers

PMID: 23171661
DOI: 10.1093/brain/aws275
PMCID: PMC3525053

Genes

FGD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells.PMID 23171661Read ↗

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