Article

<i>DNM2</i> -CMT neuropathy stems from disrupted Schwann cell function and shows limited therapeutic reversibility

2025-12-04

Abstract excerpt

Dominant loss-of-function mutations in DNM2 cause Charcot-Marie-Tooth (CMT) neuropathy characterized by sensory and motor deficits associated with myelin and/or axonal abnormalities and muscle atrophy. Increasing DNM2 activity from embryogenesis has been reported to ameliorate neuromuscular phenotypes in the Dnm2 K562E/+ CMT mouse; however, this model displays predominantly muscle pathology and limited nerve in...

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Literature Corpus work: 21ed3bac-0fb6-51a6-8946-cc5b55516ede
DOI: 10.64898/2025.12.02.691765

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