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Article

Hypogonadotropic hypogonadism and peripheral neuropathy in<i>Ebf2</i>-null mice

16 Dec 2002

Abstract excerpt

Olf/Ebf transcription factors have been implicated in numerous developmental processes, ranging from B-cell development to neuronal differentiation. We describe mice that carry a targeted deletion within the Ebf2 (O/E3) gene. In Ebf2-null mutants, because of defective migration of gonadotropin releasing hormone-synthesizing neurons, formation of the neuroendocrine axis (which is essential for pubertal...

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PMID: 12466206
DOI: 10.1242/dev.00215

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