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Article

Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

The Journal of biological chemistry - 17 Aug 2007

Cheng Irene H, Scearce-Levie Kimberly, Legleiter Justin, Palop Jorge J, Gerstein Hilary, Bien-Ly Nga, Puoliväli Jukka, Lesné Sylvain, Ashe Karen H, Muchowski Paul J, Mucke Lennart

Abstract excerpt

Many proteins suspected of causing neurodegenerative diseases exist in diverse assembly states. For most, it is unclear whether shifts from one state to another would be helpful or harmful. We used mutagenesis to change the assembly state of Alzheimer disease (AD)-associated amyloid-beta (Abeta) peptides. In vitro, the "Arctic" mutation (AbetaE22G) accelerated Abeta fibrillization but decreased the abundance of...

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PMID: 17548355
DOI: 10.1074/jbc.M701078200

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