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Article

Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancer

10 Jan 2011

Abstract excerpt

INTRODUCTION: The NEDD8 (neural precursor cell-expressed developmentally downregulated 8) conjugation pathway regulates the post-translational modification of oncogenic proteins. This pathway has important potential for cancer therapeutics. Several proteins vital in cancer biology are regulated by protein neddylation. These observations led to the development of a small molecule inhibitor that disrupts protein...

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PMID: 21219242
DOI: 10.1517/14728222.2011.550877

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