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Article

UBE2M promotes malignant phenotypes of prostate cancer through mediating NAA10 neddylation.

Journal of translational medicine - 19 Mar 2026

Wang Qixia, Zhang Junyu, Lin Xiang, Shi Ruxue, Pan Chenglong, Hu Qingxia, Xu Linlin, Chen Qiaoyun, Xue Dezhao, Yin Junling, Fu Qiang, Huang Shuhong

Abstract excerpt

BACKGROUND: Prostate cancer (PCa) is a common malignant tumor in men, with a high incidence rate, posing a serious threat to human health and quality of life. Neddylation is a major post-translation modification, which is essential for multiple cellular behaviors. Aberrant neddylation has been implicated in the development and progression of various diseases. The NEDD8-conjugating enzyme UBE2M is frequently...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41857595
DOI: 10.1186/s12967-026-08001-8
PMCID: PMC13123242

Genes

UBE2M
NAA10
CUL4A
NEDD8
RBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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