Article
UBE2M promotes malignant phenotypes of prostate cancer through mediating NAA10 neddylation.
Journal of translational medicine - 19 Mar 2026
Wang Qixia, Zhang Junyu, Lin Xiang, Shi Ruxue, Pan Chenglong, Hu Qingxia, Xu Linlin, Chen Qiaoyun, Xue Dezhao, Yin Junling, Fu Qiang, Huang Shuhong
Abstract excerpt
BACKGROUND: Prostate cancer (PCa) is a common malignant tumor in men, with a high incidence rate, posing a serious threat to human health and quality of life. Neddylation is a major post-translation modification, which is essential for multiple cellular behaviors. Aberrant neddylation has been implicated in the development and progression of various diseases. The NEDD8-conjugating enzyme UBE2M is frequently...
Topics
- Male
- Humans
- Prostatic Neoplasms
- Ubiquitin-Conjugating Enzymes
- Animals
- Cell Line, Tumor
- Phenotype
- Cell Proliferation
- N-Terminal Acetyltransferase A
- Cell Movement
- Mice, Nude
- Gene Expression Regulation, Neoplastic
- NEDD8 Protein