NEDD8-conjugating enzyme E2s: critical targets for cancer therapy

doi:10.1038/s41420-023-01337-w

Article

NEDD8-conjugating enzyme E2s: critical targets for cancer therapy

23 Jan 2023

Abstract excerpt

NEDD8-conjugating enzymes, E2s, include the well-studied ubiquitin-conjugating enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F (UBE2F). UBE2M and UBE2F have distinct and prominent roles in catalyzing the neddylation of Cullin or non-Cullin substrates. These enzymes are overexpressed in various malignancies, conferring a worse overall survival. Targeting UBE2M to influence tumor...

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