Article
Activating mutations of the Gs alpha-gene in nonfunctioning pituitary tumors.
The Journal of clinical endocrinology and metabolism - 1 Sept 1993
Tordjman K, Stern N, Ouaknine G, Yossiphov Y, Razon N, Nordenskjöld M, Friedman E
Abstract excerpt
The majority of pituitary tumors are of monoclonal origin; however, the molecular basis for their formation is poorly understood. Somatic mutations in the alpha-subunit of the GTP-binding protein, Gs alpha (gsp oncogene) have been found in about one third of GH-secreting tumors. Mutations in anot...
Topics
- Adrenocorticotropic Hormone
- Adult
- Aged
- Base Sequence
- Codon
- Electrophoresis, Polyacrylamide Gel
- Exons
- Female
- Follicle Stimulating Hormone
- GTP-Binding Proteins
- Growth Hormone
- Humans
- Immunoenzyme Techniques
- Luteinizing Hormone
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation