Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insights into the pathogenesis of XXY phenotype from comparison of the clinical syndrome with an experimental XXY mouse model.

Pediatric endocrinology reviews : PER - 1 Dec 2010

Lue Yan-he, Wang Christina, Liu Peter Y, Erkilla Krista, Swerdloff Ronald S

Abstract excerpt

Klinefelter syndrome (47, XXY male) is the most common sex chromosome disorder in men. To study the underlying mechanisms of XXY phenotypes and design specific and novel therapeutic regimens for KS men, an experimental mouse model (41, XXY) was established. This manuscript compares the phenotypes of XXY men and mice and discusses the possible contributions of low androgen levels and extra X chromosome genes to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chimera
Share to Chromosomes, Human, X

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Klinefelter Syndrome

Share to Mice, Inbred BALB C

Share to Sex Chromosome Aberrations

Share to Trisomy

Source

Identifiers

PMID: 21217605

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insights into the pathogenesis of XXY phenotype from comparison of the clinical syndrome with an experimental XXY mouse model.PMID 21217605Read ↗

Mouse model for men with klinefelter syndrome: a multifaceted fit for a complex disorder.Semantic proximity Read ↗

XXY male mice: an experimental model for Klinefelter syndrome.Semantic proximity Read ↗

Male 41, XXY* Mice as a Model for Klinefelter Syndrome: Hyperactivation of Leydig CellsSemantic proximity Read ↗

XXY mice exhibit gonadal and behavioral phenotypes similar to Klinefelter syndrome.Semantic proximity Read ↗

Mouse models for evaluating sex chromosome effects that cause sex differences in non-gonadal tissues.Semantic proximity Read ↗

Animal models for Klinefelter's syndrome and their relevance for the clinicSemantic proximity Read ↗

Expression of selected genes escaping from X inactivation in the 41, XXY* mouse model for Klinefelter’s syndromeSemantic proximity Read ↗

The Sex Chromosome Trisomy mouse model of XXY and XYY: metabolism and motor performanceSemantic proximity Read ↗

Establishment of an iPSC cohort from three unrelated 47-XXY Klinefelter Syndrome patients (KAUSTi007-A, KAUSTi007-B, KAUSTi009-A, KAUSTi009-B, KAUSTi010-A, KAUSTi010-B).Semantic proximity Read ↗

First wild XXY house mice.Semantic proximity Read ↗

Four Core Genotypes and XY* mouse models: Update on impact on SABV research.Semantic proximity Read ↗

Therapy of endocrine disease: Testicular function and fertility in men with Klinefelter syndrome: a reviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.