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Article

Therapy of endocrine disease: Testicular function and fertility in men with Klinefelter syndrome: a review

16 Mar 2013

Abstract excerpt

Klinefelter syndrome, 47,XXY (KS), is the most frequent sex chromosome aberration in males, affecting 1 in 660 newborn boys. The syndrome is characterized by testicular destruction with extensive fibrosis and hyalinization of the seminiferous tubules resulting in small testes, hypergonadotropic hypogonadism, and azoospermia in the majority of cases. Until recently, infertility was considered an untreatable...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 23504510
DOI: 10.1530/eje-12-0934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Therapy of endocrine disease: Testicular function and fertility in men with Klinefelter syndrome: a reviewPMID 23504510Read ↗

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