Article
XXY male mice: an experimental model for Klinefelter syndrome.
Endocrinology - 1 Apr 2001
Lue Y, Rao P N, Sinha Hikim A P, Im M, Salameh W A, Yen P H, Wang C, Swerdloff R S
Abstract excerpt
Klinefelter syndrome (47,XXY) is the most common sex chromosome aneuploidy in men. Thus, it is important to establish an experimental animal model to explore its underlying molecular mechanisms. Mice with a 41,XXY karyotype were produced by mating wild-type male mice with chimeric female mice carrying male embryonic stem cells. The objectives of the present study were to characterize the testicular phenotype of...
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