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Article

Expression of selected genes escaping from X inactivation in the 41, XXY* mouse model for Klinefelter’s syndrome

17 Jan 2011

Abstract excerpt

AIM: We hypothesized that patients with Klinefelter's syndrome (KS) not only undergo X inactivation, but also that genes escape from inactivation. Their transcripts would constitute a significant difference, as male metabolism is not adapted to a 'female-like' gene dosage. We evaluated the expression of selected X-linked genes in our 41, XX(Y)* male mice to determine whether these genes escape inactivation and...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Identifiers

PMID: 21241365
DOI: 10.1111/j.1651-2227.2010.02112.x

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