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Article

XXY mice exhibit gonadal and behavioral phenotypes similar to Klinefelter syndrome.

Endocrinology - 1 Sept 2005

Lue Yanhe, Jentsch J David, Wang Christina, Rao P Nagesh, Hikim Amiya P Sinha, Salameh Wael, Swerdloff Ronald S

Abstract excerpt

Klinefelter syndrome (XXY males) is the most common sex chromosome aneuploidy. XXY mice were generated by using a four-generation breeding scheme that involves the use of a structurally rearranged Y chromosome, Y*, yielding approximately 50% of the live-born male offspring in the fourth generation with a XXY karyotype. Adult XXY mice have small testes, decreased plasma T levels, and elevated plasma FSH levels....

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Source

Identifiers

PMID: 15961558
DOI: 10.1210/en.2005-0278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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