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Article

Frequency of the SLCO1B1 388A>G and the 521T>C polymorphism in Tanzania genotyped by a new LightCycler®-based method.

European journal of clinical pharmacology - 1 Nov 2011

Aklillu Eleni, Mugusi Sabina, Ngaimisi Eliford, Hoffmann Michael Marcus, König Sonja, Ziesenitz Victoria, Mikus Gerd, Haefeli Walter Emil, Weiss Johanna

Abstract excerpt

PURPOSE: The 388A>G and the 521T>C polymorphism of the SLCO1B1 gene affect the activity of the uptake transporter OATP1B1, thus influencing kinetics, safety, and efficacy of substrate drugs. To evaluate the impact of these polymorphisms in populations of different ethnic origins, it is important to know their frequencies and to develop fast and reliable methods for genotyping. We therefore established a new,...

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Identifiers

PMID: 21630030
DOI: 10.1007/s00228-011-1065-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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