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International Transporter Consortium Commentary on Clinically Important Transporter Polymorphisms

19 Jun 2013

Abstract excerpt

This Commentary focuses on genetic polymorphisms in membrane transporters. We present two polymorphisms for which there is a compelling body of literature supporting their clinical relevance: OATP1B1 (c.521T>C, p.V174A, rs4149056) and BCRP (c.421C>A, p.Q141K, rs2231142). The clinical evidence demonstrating their role in variation in pharmacokinetics and pharmacodynamics is described along with their allele...

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PMID: 23778707
DOI: 10.1038/clpt.2013.12

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