Article

Dexamethasone Enhances CAR T Cell Persistence and Function by Upregulating Interleukin 7 Receptor

2022-08-29

Abstract excerpt

Dexamethasone (dex) is a glucocorticoid that is a mainstay for treatment of inflammatory pathologies, including immunotherapy-associated toxicities. Dex suppresses the endogenous immune response and is also believed to suppress the function of chimeric antigen receptor (CAR) T cells. However, recent reports observed higher CAR T cell numbers in patients treated with dex, highlighting the rationale for interrogatin...

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Literature Corpus work: 7cfcc060-8a2a-573f-87ce-d8f3d20a9cdc
DOI: 10.1101/2022.08.29.505735

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