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Article

Dystroglycan organizes axon guidance cue localization and axonal pathfinding.

Neuron - 6 Dec 2012

Wright Kevin M, Lyon Krissy A, Leung Haiwen, Leahy Daniel J, Ma Le, Ginty David D

Abstract excerpt

Precise patterning of axon guidance cue distribution is critical for nervous system development. Using a murine forward genetic screen for novel determinants of axon guidance, we identified B3gnt1 and ISPD as required for the glycosylation of dystroglycan in vivo. Analysis of B3gnt1, ISPD, and dystroglycan mutant mice revealed a critical role for glycosylated dystroglycan in the development of several...

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Identifiers

PMID: 23217742
DOI: 10.1016/j.neuron.2012.10.009
PMCID: PMC3526105

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