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Article

Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase.

Science (New York, N.Y.) - 2 Jul 2004

Chang Chieh, Yu Timothy W, Bargmann Cornelia I, Tessier-Lavigne Marc

Abstract excerpt

During axon guidance, the ventral guidance of the Caenorhabditis elegans anterior ventral microtubule axon is controlled by two cues, the UNC-6/netrin attractant recognized by the UNC-40/DCC receptor and the SLT-1/slit repellent recognized by the SAX-3/robo receptor. We show here that loss-of-function mutations in clr-1 enhance netrin-dependent attraction, suppressing ventral guidance defects in slt-1 mutants....

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Source

Identifiers

PMID: 15232111
DOI: 10.1126/science.1096983

Genes

DCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase.PMID 15232111Read ↗

Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function.Semantic proximity Read ↗

UNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans.Semantic proximity Read ↗

The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction.Semantic proximity Read ↗

Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline.Semantic proximity Read ↗

Extracellular matrix regulates UNC-6 (netrin) axon guidance by controlling the direction of intracellular UNC-40 (DCC) outgrowth activity.Semantic proximity Read ↗

ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans.Semantic proximity Read ↗

UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites.Semantic proximity Read ↗

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