Article
Access to the nucleus and functional association with c-Myc is required for the full oncogenic potential of ΔEGFR/EGFRvIII.
The Journal of biological chemistry - 1 Feb 2013
Gururaj Anupama E, Gibson Laura, Panchabhai Sonali, Bai MingHui, Manyam Ganiraju, Lu Yue, Latha Khatri, Rojas Marta L, Hwang Yeohyeon, Liang Shoudan, Bogler Oliver
Abstract excerpt
ΔEGFR is a potent glioblastoma oncogene which has been studied primarily as a plasma membrane kinase. Using intracranial xenograft studies in mice, we show that blocking ΔEGFR access to the nucleus attenuates its tumorigenicity and, conversely, that promoting nuclear accumulation enhances this, providing the first in vivo evidence that the nuclear actions of ΔEGFR contribute strongly to its oncogenic function....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.