Article

Inversed impaired osteogenic activity in children with severe obesity due to MC4R deficiency compared to LEP and LEPR deficiency

2025-05-20

Abstract excerpt

<title>Abstract</title> <p> <bold>OBJECTIVE</bold> Chronic obesity is associated with impaired bone health. However, few investigations have been conducted to assess bone physiology in early-onset obesity. In this study, we measured specific bone turnover and metabolic biomarkers in children with severe obesity with biallelic loss-of-function variants of the leptin ( <italic>LEP)</italic> , leptin receptor <...

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Literature Corpus work: da339538-ddb6-5335-8b34-6d8db248bbce
DOI: 10.21203/rs.3.rs-6595544/v1

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