Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simulating sequences of the human genome with rare variants.

Human heredity - 1 Jan 2010

Peng Bo, Liu Xiaoming

Abstract excerpt

OBJECTIVE: Simulated samples have been widely used in the development of efficient statistical methods identifying genetic variants that predispose to human genetic diseases. Although it is well known that natural selection has a strong influence on the number and diversity of rare genetic variations in human populations, existing simulation methods are limited in their ability to simulate multi-locus selection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Computer Simulation
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Variation

Share to Genome, Human

Share to Models, Genetic

Share to Software

Source

Open in PubMed Open full text

Identifiers

PMID: 21212684
DOI: 10.1159/000323316
PMCID: PMC3164177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simulating sequences of the human genome with rare variants.PMID 21212684Read ↗

Population genetic simulations of complex phenotypes with implications for rare variant association tests.Semantic proximity Read ↗

RAREsim: A simulation method for very rare genetic variants.Semantic proximity Read ↗

RAREsim: A simulation method for very rare genetic variantsSemantic proximity Read ↗

Forward-time simulations of human populations with complex diseases.Semantic proximity Read ↗

Forward-time simulation of realistic samples for genome-wide association studies.Semantic proximity Read ↗

Population genetics of rare variants and complex diseases.Semantic proximity Read ↗

A multi-scenario genome-wide medical population genetics simulation framework.Semantic proximity Read ↗

Reproducible simulations of realistic samples for next-generation sequencing studies using Variant Simulation Tools.Semantic proximity Read ↗

An overview of population genetic data simulation.Semantic proximity Read ↗

GeneEvolve: a fast and memory efficient forward-time simulator of realistic whole-genome sequence and SNP data.Semantic proximity Read ↗

Genome simulation approaches for synthesizing in silico datasets for human genomics.Semantic proximity Read ↗

Simulating realistic genomic data with rare variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.