Article
A multi-scenario genome-wide medical population genetics simulation framework.
Bioinformatics (Oxford, England) - 1 Oct 2017
Mugo Jacquiline W, Geza Ephifania, Defo Joel, Elsheikh Samar S M, Mazandu Gaston K, Mulder Nicola J, Chimusa Emile R
Abstract excerpt
MOTIVATION: Recent technological advances in high-throughput sequencing and genotyping have facilitated an improved understanding of genomic structure and disease-associated genetic factors. In this context, simulation models can play a critical role in revealing various evolutionary and demographic effects on genomic variation, enabling researchers to assess existing and design novel analytical approaches....
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