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Article

Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2011

Akiyoshi Takeshi, Saito Takashi, Murase Saori, Miyazaki Mitsue, Murayama Norie, Yamazaki Hiroshi, Guengerich F Peter, Nakamura Katsunori, Yamamoto Koujirou, Ohtani Hisakazu

Abstract excerpt

CYP3A4, an important drug-metabolizing enzyme, is known to have genetic variants. We have previously reported that CYP3A4 variants such as CYP3A4.2, 7, 16, and 18 show different enzymatic kinetics from CYP3A4.1 (wild type). In this study, we quantitatively investigated the inhibition kinetics of...

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PMID: 21212239
DOI: 10.1124/dmd.110.036780
PMCID: PMC3063718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21212239-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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