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Article

Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants.

Drug metabolism and pharmacokinetics - 1 Jun 2021

Yamaguchi Yuki, Akiyoshi Takeshi, Kawamura Go, Imaoka Ayuko, Miyazaki Mitsue, Guengerich F Peter, Nakamura Katsunori, Yamamoto Koujirou, Ohtani Hisakazu

Abstract excerpt

Cytochrome P450 (CYP) 3A4 is one of the major drug-metabolizing enzymes. Genetic variants of CYP3A4 with altered activity are one of the factors responsible for interindividual differences in drug metabolism. Azole antifungals inhibit CYP3A4 to cause clinically significant drug-drug interactions. In the present quantitative study, we investigated the inhibitory effects of three azole antifungals (ketoconazole,...

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Identifiers

PMID: 33826998
DOI: 10.1016/j.dmpk.2021.100384
PMCID: PMC8144059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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