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Article

Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems.

Current drug metabolism - 1 Jan 2024

Wen Jinhua, Xiao Yuwei, Zhao Menghua, Yang Chen, Hu Weiqiang

Abstract excerpt

OBJECTIVE: This study aimed to investigate the effects of clarithromycin and ketoconazole on the pharmacokinetic properties of tacrolimus in different CYP3A4 genotype recombinant metabolic enzyme systems, so as to understand the drug interactions and their mechanisms further. METHOD: The experiment was divided into three groups: a blank control group, CYP3A4*1 group and CYP3A4*18 recombinant enzyme group. Each...

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Identifiers

PMID: 38523538
DOI: 10.2174/0113892002286019240315052145

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