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Article

Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice.

Neurochemical research - 1 Jul 2011

He Xiaojuan, Takahashi Satoru, Suzuki Hiromi, Hashikawa Tsutomu, Kulkarni Ashok B, Mikoshiba Katsuhiko, Ohshima Toshio

Abstract excerpt

Cyclin-dependent kinase 5 (Cdk5) plays a pivotal role in neuronal migration and differentiation, and in axonal elongation. Although many studies have been conducted to analyze neuronal functions of Cdk5, its kinase activity has also been reported during oligodendrocyte differentiation, which suggests Cdk5 may play an important role in oligodendrocytes. Here, we describe a hypomyelination phenotype observed in...

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Identifiers

PMID: 21210220
DOI: 10.1007/s11064-010-0391-0
PMCID: PMC3431604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice.PMID 21210220Read ↗

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