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Article

Disruption of the mitotic kinesin Eg5 gene (Knsl1) results in early embryonic lethality.

Biochemical and biophysical research communications - 8 Aug 2008

Chauvière Muriel, Kress Chantal, Kress Michel

Abstract excerpt

Eg5, a member of the widely conserved kinesin-5 family, is a plus-end-directed motor involved in separation of centrosomes, and in bipolar spindle formation and maintenance during mitosis in vertebrates. To investigate the requirement for Eg5 in mammalian development, we have generated Eg5 deficient mice by gene targeting. Heterozygous mice are healthy, fertile, and show no detectable phenotype, whereas Eg5(-/-)...

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Source

Identifiers

PMID: 18474226
DOI: 10.1016/j.bbrc.2008.04.177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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