Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects

5 Apr 2004

Abstract excerpt

Cyclin-dependent kinase 5 (Cdk5) is essential for the proper development of the CNS, as is evident from the perinatal lethality of conventional Cdk5 knockout (Cdk5-/-) mice. Cdk5 is also implicated in numerous complex functions of the adult CNS such as synaptic transmission, synaptic plasticity, and neuronal signaling. To elucidate the molecular roles of Cdk5 in the adult CNS, we have abrogated neuronal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to MicroRNA in disease regulation
Share to Neurogenesis and neuroplasticity mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15067135
DOI: 10.1073/pnas.0307322101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defectsPMID 15067135Read ↗

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.Semantic proximity Read ↗

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.Semantic proximity Read ↗

CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders.Semantic proximity Read ↗

p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic ResponsesSemantic proximity Read ↗

CDK5: A Unique CDK and Its Multiple Roles in the Nervous SystemSemantic proximity Read ↗

Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice.Semantic proximity Read ↗

Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.Semantic proximity Read ↗

Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder.Semantic proximity Read ↗

Transcriptomic Profiling of Zebrafish Mutant for cdkl5 Reveals Dysregulated Gene Expression Associated with Neuronal, Muscle, Visual and Skeletal DevelopmentSemantic proximity Read ↗

A kinase of many talents: non-neuronal functions of CDK5 in development and diseaseSemantic proximity Read ↗

Deficiency of cyclin-dependent kinase-like 5 causes spontaneous epileptic seizures in neonatal miceSemantic proximity Read ↗

Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency DisorderSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.