Article
ATF5 regulates the proliferation and differentiation of oligodendrocytes.
Molecular and cellular neurosciences - 1 Jul 2005
Mason Jeffrey L, Angelastro James M, Ignatova Tatyana N, Kukekov Valery G, Lin Grace, Greene Lloyd A, Goldman James E
Abstract excerpt
The transcription factor ATF5 is expressed in cells of the embryonic and neonatal ventricular zone/subventricular zone (VZ/SVZ), and must be down-regulated for their differentiation into neurons and astrocytes. Here, we show that ATF5 plays a major role in directing oligodendrocyte development. ATF5 is expressed by oligodendrocyte precursors but is absent from mature oligodendroglia. Constitutively expressed ATF5...
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