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Article

Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease.

Obesity (Silver Spring, Md.) - 1 Oct 2011

de Miguel-Yanes Jose M, Manning Alisa K, Shrader Peter, McAteer Jarred B, Goel Anuj, Hamsten Anders, Fox Caroline S, Florez Jose C, Dupuis Josée, Meigs James B

Abstract excerpt

Inhibition of the endocannabinoid receptor CB1 improves insulin sensitivity, lowers glycemia, and slows atherosclerosis. We analyzed whether common variants in the gene encoding CB1, CNR1, are associated with insulin resistance, risk of type 2 diabetes (T2D) or coronary heart disease (CHD). We studied 2,411 participants of the Framingham Offspring Study (mean age 60 years, 52% women) for quantitative traits and...

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Identifiers

PMID: 21633404
DOI: 10.1038/oby.2011.135
PMCID: PMC3686489

Genes

CNR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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