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Article

Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2011

Englert Markus, Sheppard Kelly, Aslanian Aaron, Yates John R, Söll Dieter

Abstract excerpt

Intron removal from tRNA precursors involves cleavage by a tRNA splicing endonuclease to yield tRNA 3'-halves beginning with a 5'-hydroxyl, and 5'-halves ending in a 2',3'-cyclic phosphate. A tRNA ligase then incorporates this phosphate into the internucleotide bond that joins the two halves. Alt...

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Identifiers

PMID: 21209330
DOI: 10.1073/pnas.1018307108
PMCID: PMC3029724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21209330-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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