Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct evidence for translational regulation by leader RNA and Tat protein of human immunodeficiency virus type 1.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1990

SenGupta D N, Berkhout B, Gatignol A, Zhou A M, Silverman R H

Abstract excerpt

Translational effects of the RNA leader and Tat protein of human immunodeficiency virus type 1 (HIV-1) were investigated in rabbit reticulocyte lysate. Hybrid RNA species with natural or mutated HIV-1 leader fused to human interferon- gamma mRNA were produced in vitro from recombinant plasmids. HIV-1 leader RNA was found to inhibit translation through two mechanisms. A 3-fold trans-inhibition of translation was...

Topics

Animals
Gene Expression Regulation, Viral
Gene Products, tat
HIV-1
Humans
Interferon-gamma
Kinetics
Mutation
Plasmids
Protein Biosynthesis
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rabbits

Recombinant Fusion Proteins

Reticulocytes

tat Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 2120701
DOI: 10.1073/pnas.87.19.7492
PMCID: PMC54773

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2120701-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Direct evidence for translational regulation by leader RNA and Tat protein of human immunodeficiency virus type 1.PMID 2120701Read ↗

Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distanceSemantic proximity Read ↗

Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein.Semantic proximity Read ↗

Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs.Semantic proximity Read ↗

The TAR RNA-binding protein, TRBP, stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR.Semantic proximity Read ↗

The 5′ UTR of HIV-1 full-length mRNA and the Tat viral protein modulate the programmed −1 ribosomal frameshift that generates HIV-1 enzymesSemantic proximity Read ↗

The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation.Semantic proximity Read ↗

Inhibition of CD4 translation mediated by human immunodeficiency virus type 1 envelope protein in a cell-free system.Semantic proximity Read ↗

Detection, characterization and regulation of antisense transcripts in HIV-1Semantic proximity Read ↗

Tat functions to stimulate the elongation properties of transcription complexes paused by the duplicated TAR RNA element of human immunodeficiency virus 2.Semantic proximity Read ↗

Mechanism of interferon action. Translational control and the RNA-dependent protein kinase (PKR): antagonists of PKR enhance the translational activity of mRNAs that include a 161 nucleotide region from reovirus S1 mRNA.Semantic proximity Read ↗

A nuclear translational block imposed by the HIV-1 U3 region is relieved by the Tat-TAR interaction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.