Tat functions to stimulate the elongation properties of transcription complexes paused by the duplicated TAR RNA element of human immunodeficiency virus 2.

doi:10.1006/jmbi.1995.0622

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Article

Tat functions to stimulate the elongation properties of transcription complexes paused by the duplicated TAR RNA element of human immunodeficiency virus 2.

Journal of molecular biology - 1 Dec 1995

García-Martínez L F, Mavankal G, Peters P, Wu-Baer F, Gaynor R B

Abstract excerpt

In this study we have defined the in vitro requirements for transcriptional regulation of the HIV-2 LTR in response to the HIV-1 and HIV-2 Tat proteins and addressed potential mechanisms of Tat function. HIV-2 contains a duplicated TAR RNA stem-loop structure in contrast to the single stem-loop s...

Topics

Base Sequence
Gene Expression Regulation, Viral
Gene Products, tat
HIV Long Terminal Repeat
HIV-1
HIV-2
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Nuclear Proteins
Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Protein Binding

RNA Precursors

RNA, Viral

RNA-Binding Proteins

Species Specificity

Source

Open in PubMed

Identifiers

PMID: 7490754
DOI: 10.1006/jmbi.1995.0622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7490754-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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