Article
A nuclear translational block imposed by the HIV-1 U3 region is relieved by the Tat-TAR interaction.
Cell - 21 Sept 1990
Braddock M, Thorburn A M, Chambers A, Elliott G D, Anderson G J, Kingsman A J, Kingsman S M
Abstract excerpt
Replication of HIV-1 depends on the viral Tat protein, which functions via a target sequence, TAR, present in the proviral long terminal repeat (LTR) and at the 5' end of viral mRNAs. We have shown that Tat potentiates the expression of TAR-containing RNAs, but only when Tat and the TAR-containin...
Topics
- Animals
- Base Sequence
- Cell Nucleus
- Cell Transformation, Viral
- DNA, Viral
- Female
- Gene Products, tat
- HIV-1
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Oligonucleotide Probes
- Oocytes
- Plasmids
- Promoter Regions, Genetic
- Protein Biosynthesis
- Proviruses
- RNA, Messenger