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Article

Complex interplay between -catenin signalling and Notch effectors in intestinal tumorigenesis

4 Jan 2011

Abstract excerpt

AIMS: The activation of β-catenin signalling is a key step in intestinal tumorigenesis. Interplay between the β-catenin and Notch pathways during tumorigenesis has been reported, but the mechanisms involved and the role of Notch remain unclear. METHODS: Notch status was analysed by studying expression of the Notch effector Hes1 and Notch ligands/receptors in human colorectal cancer (CRC) and mouse models of Apc...

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Identifiers

PMID: 21205878
DOI: 10.1136/gut.2009.204719

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