Article
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation.
Nature genetics - 1 Mar 2004
van den Brink Gijs R, Bleuming Sylvia A, Hardwick James C H, Schepman Berber L, Offerhaus G Johan, Keller Josbert J, Nielsen Corinne, Gaffield William, van Deventer Sander J H, Roberts Drucilla J, Peppelenbosch Maikel P
Abstract excerpt
Wnt signaling defines the colonic epithelial progenitor cell phenotype, and mutations in the gene adenomatous polyposis coli (APC) that activate the Wnt pathway cause the familial adenomatous polyposis coli (FAP) syndrome and most sporadic colon cancers. The mechanisms that regulate the transition of epithelial precursor cells into their differentiated derivatives are poorly characterized. We report that Indian...
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