Article
Gene expression profiling of yeasts overexpressing wild type or misfolded Pma1 variants reveals activation of the Hog1 MAPK pathway.
Molecular microbiology - 1 Mar 2011
Eraso Pilar, Mazón María J, Posas Francesc, Portillo Francisco
Abstract excerpt
Dominant negative PMA1 mutants render misfolded proteins that are retained in the endoplasmic reticulum (ER) and slowly degraded by ER-associated degradation. Accumulation of misfolded proteins in the ER activates an ER-to-nucleus signalling pathway termed the unfolded protein response (UPR). We...
Topics
- Endoplasmic Reticulum
- Enzyme Activation
- Gene Expression
- Gene Expression Profiling
- Genetic Variation
- MAP Kinase Signaling System
- Mitogen-Activated Protein Kinases
- Protein Folding
- Proton-Translocating ATPases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins