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Article

Eps1, a novel PDI-related protein involved in ER quality control in yeast.

The EMBO journal - 1 Nov 1999

Wang Q, Chang A

Abstract excerpt

PMA1 is an essential gene encoding the yeast plasma membrane [H(+)]ATPase. A pma1-D378N mutant has a dominant-negative effect on cell growth because both newly synthesized mutant and wild-type Pma1 molecules are retained and degraded in the endoplasmic reticulum (ER). Like other substrates for ER-associated degradation, Pma1-D378N is stabilized in mutants defective in components of the ubiquitination machinery. A...

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Identifiers

PMID: 10545109
DOI: 10.1093/emboj/18.21.5972
PMCID: PMC1171663

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