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Article

Characterization of two second-site mutations preventing wild type protein aggregation caused by a dominant negative PMA1 mutant.

PloS one - 1 Jan 2013

Eraso Pilar, Portillo Francisco, Mazón María J

Abstract excerpt

The correct biogenesis and localization of Pma1 at the plasma membrane is essential for yeast growth. A subset of PMA1 mutations behave as dominant negative because they produce aberrantly folded proteins that form protein aggregates, which in turn provoke the aggregation of the wild type protein. One approach to understand this dominant negative effect is to identify second-site mutations able to suppress the...

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Identifiers

PMID: 23825623
DOI: 10.1371/journal.pone.0067080
PMCID: PMC3692421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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