Article
The activity of yeast Hog1 MAPK is required during endoplasmic reticulum stress induced by tunicamycin exposure.
The Journal of biological chemistry - 25 Jun 2010
Torres-Quiroz Francisco, García-Marqués Sara, Coria Roberto, Randez-Gil Francisca, Prieto Jose A
Abstract excerpt
Accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the so-called unfolded protein response (UPR), a conserved signaling pathway that drives the transcription of genes such as chaperones and folding enzymes. Nevertheless, the activity of the UPR accounts only for a part of the gene expression program activated upon ER stress. Moreover, the mechanism(s) for how cells adapt and survive to...
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