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Article

Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics.

Molecular pharmacology - 1 Apr 2017

Li Ni, Wang Xiao, Xu Yanni, Lin Yuan, Zhu Ningyu, Liu Peng, Lu Duo, Si Shuyi

Abstract excerpt

Activation of liver X receptor (LXR) is associated with cholesterol metabolism and anti-inflammatory processes, which makes it beneficial to antiatherosclerosis therapy. Nevertheless, existing agonists that target LXR, for example TO901317, are related to unwanted side effects. In the present study, using a screening method we identified IMB-808, which displayed potent dual LXRα/β agonistic activity. In vitro,...

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Identifiers

PMID: 28087808
DOI: 10.1124/mol.116.105213

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